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A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted. Those trials compared taking rimonabant (20 milligrams a day) against a placebo. Rimonabant is not yet accustomed for use in the United States, area it is accepted as Zimulti. Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight.

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